What genus are you working with? If they brown in 72 hours I'd say it is definitely a problem with the replate media. As Montera suggests, It could be a pH problem but that affects nutrient availibility so I'd guess it would show effects more slowly.
My guess, the replate media is too strong and is giving the sensitive little guys fertilizer burn. Try making your replate fourmula at about 75 or 80% strength. You might have to add back a bit more agar if you want it really stiff but I use it on the soft side and it works just fine with most.
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